Microsatellite DNA instability and COPD exacerbations
نویسندگان
چکیده
منابع مشابه
Microsatellite DNA instability and COPD exacerbations.
Increased frequency of microsatellite DNA instability (MSI) has been detected in the sputum of chronic obstructive pulmonary disease (COPD) patients. The aim of the present study was to investigate the relationship between MSI in sputum cells and exacerbation frequency, which is an important parameter in the clinical course of the disease. Induced sputum samples and peripheral blood obtained fr...
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Genetic alterations in the microsatellite DNA level have been successfully detected in sputum samples of patients with COPD and have been shown to be disease specific. Furthermore, previous studies have shown that inflammation coexists in the nasal mucosa of patients with COPD. The aim of this study was to assess the presence of MSI in nasal cytological samples of patients with COPD comparing t...
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Mismatch (MMR) repair system plays a significant role in restoration of stability in the genome. Mutations in mismatch repair genes hamper their activity thus bring about a defect in mismatch repair (MMR) mechanism thereby conferring instability in the microsatellite sequences of both the coding and non-coding regions of the genome. Mutated mismatch repair genes result in the expansion or contr...
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n engl j med 372;1 nejm.org january 1, 2015 92 for transfusion in our clinical setting.3 The benefit of using the lactate level and Scvo2 to initiate and guide early resuscitation, including transfusion, in patients with septic shock may be questioned after the results of recent randomized trials.4,5 As compared with the high-quality data from these trials, the results of any post hoc subgroup ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2008
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00169307